STILLWATER, Okla. — Freshman swingman Le'Bryan Nash scored a career-high 27 points, Brian Williams added a career-best 22 and Oklahoma State knocked off No. 2 Missouri 79-72 on Wednesday night.

STILLWATER, Okla. — Freshman swingman Le'Bryan Nash scored a career-high 27 points, Brian Williams added a career-best 22 and Oklahoma State knocked off No. 2 Missouri 79-72 on Wednesday night.

Nash, a McDonald's All-American, scored 13 points during a 17-4 burst that sent the Cowboys into the lead in the final 4 minutes and the Tigers (18-2, 5-2 Big 12) didn't have a response.

Nash hit a jumper and a 3-pointer to get it going, then nailed another 3 from the left side to give the Cowboys (10-10, 3-4) a 65-64 lead with 3:23 to play. He connected on another 29 seconds later and ran to the opposite end of the court when Missouri called timeout to encourage a student section that was already hopping up and down to bring it on.

When the clock hit zero, the students rushed the court and huddled around Oklahoma State's players at midcourt.

No. 4 Ohio State 78,Penn State 54

At Columbus, Ohio, Jared Sullinger had 20 points and 13 rebounds, and Ohio State took advantage of Penn State's slow start.

The Buckeyes (18-3, 6-2 Big Ten) won their third in a row and fifth in six games while tuning up for Sunday's big home showdown with No. 20 Michigan. The Wolverines, Ohio State and Michigan State came into the week tied for the top spot in the Big Ten.

William Buford added 15 points and Aaron Craft had 11 — all in the first half — as the Buckeyes built a lopsided lead.

Big Ten scoring leader Tim Frazier had 16 points for Penn State (10-12, 2-7), which has lost its last 17 meetings with Ohio State.

No. 8 Duke 74, Maryland 61

At College Park, Md., Mason Plumlee scored 23 points and Duke averted its first losing streak of the season by pulling away from Maryland.

Seeking to rebound from a rare home loss against Florida State, the Blue Devils trailed 47-46 with 12:54 left but outscored Maryland 28-14 the rest of the way.

Ryan Kelly had 14 points and Austin Rivers 10 for Duke (17-3, 5-1 Atlantic Coast Conference). The Blue Devils have dominated this rivalry of late, winning four straight and 10 of 11.

No. 10 Michigan State 68, Minnesota 52

At East Lansing, Mich., Draymond Green had 22 points, 14 rebounds and six assists to help Michigan State beat Minnesota and give coach Tom Izzo his 400th win.

Izzo downplayed what the milestone meant to him on Monday, but was wiping tears off his cheeks during the final seconds of the victory.

The Spartans (17-4, 6-2) moved into a first-place tie in the Big Ten with their second straight win after losing two in a row.

The Golden Gophers (15-6, 3-5) had won three straight, including their previous two on the road. Rodney Williams scored 15 points for Minnesota.