CHICAGO — Kevin Youkilis hit a grand slam, Jarrod Saltalamacchia homered twice and Boston roughed up Chicago starter Philip Humber during a 10-3 victory on Thursday.

CHICAGO — Kevin Youkilis hit a grand slam, Jarrod Saltalamacchia homered twice and Boston roughed up Chicago starter Philip Humber during a 10-3 victory on Thursday.

Youkilis, mired in an early slump, hit his second career slam during a five-run third inning against Humber, who was making his first start since pitching a perfect game in a 4-0 victory at Seattle on Saturday.

There was no such suspense this time. Humber (1-1) walked leadoff batter Mike Aviles in the first, snapping his streak of 29 straight batters retired.

Mariners 5, Tigers 4

At Detroit, Chone Figgins hit a tiebreaking double in the seventh inning that was misjudged by right fielder Brennan Boesch, and Seattle completed a three-game sweep of Detroit.

Figgins' drive to right-center scored Brendan Ryan, who reached on a two-out walk from Pick Porcello (1-2). Former Tiger Charlie Furbush (1-1) got the win with a perfect inning of work.

Giants 6, Reds 5

At Cincinnati, Angel Pagan hit a three-run homer in the ninth inning, lifting San Francisco to the win over Cincinnati.

Joaquin Arias led off the ninth against Cincinnati closer Sean Marshall (0-2) with a walk, and Ryan Theriot followed with a single. After pinch-hitter Brett Pill struck out, Pagan lofted a 1-2 pitch into the left field seats to snap the Giants' losing streak in Cincinnati at seven.

Javier Lopez (2-0) allowed two hits but no runs in the eighth to earn the win. Santiago Casilla struck out the side in the ninth for his second save in two opportunities.

Jay Bruce hit a two-run homer in the sixth for the Reds and Scott Rolen added a solo shot.

PADRES 2, NATIONALS 1

SAN DIEGO — Pinch-hitter Mark Kotsay's two-run double off reliever Tyler Clippard in the eighth inning lifted San Diego over Washington.

With the Padres trailing 1-0, Orlando Hudson drew a one-out walk and Cameron Maybin dropped down a bunt single against Clippard (1-2). Kotsay followed with a double to right-center.

Andrew Cashner (1-1) pitched a perfect eighth and Huston Street earned his second save. Three pitchers combined on a four-hitter for San Diego, which improved to 6-14 and averted a three-game sweep.

The NL East-leading Nationals (14-5) had won four straight and eight of 10.

Jayson Werth's home run in the seventh off Padres starter Edinson Volquez snapped a scoreless tie. Edwin Jackson pitched 6 2-3 shutout innings for the Nationals, who have eight scoreless starts in 19 games this season.

AP-WF-04-27-12 0537GMT