CLEVELAND — Josh Donaldson hit a three-run homer and five Oakland Athletics pitchers combined to beat the Cleveland Indians 8-4 on Wednesday.

CLEVELAND — Josh Donaldson hit a three-run homer and five Oakland Athletics pitchers combined to beat the Cleveland Indians 8-4 on Wednesday.

Oakland took over the AL wild-card lead by one game over Baltimore with its 11th win in 13 games as Travis Blackley (5-3) gave up two runs over 52/3 innings. Ryan Cook got four outs for his 13th save.

Donaldson connected off rookie Corey Kluber (0-3) in the fourth inning for a 3-2 lead. Shoddy fielding by the Indians, losers of 13 of 14, helped the Athletics later extend the lead.

Jason Donald's homer in the third broke the Indians' 24-inning scoreless streak, but they fell to 5-26 since July 27.

Twins 10, Mariners 0

At Minneapolis, Samuel Deduno dominated for seven innings, Trevor Plouffe homered and had four RBIs, and the Twins beat the Mariners.

The normally wild Deduno (5-2) struck out a career-high nine with no walks to help the win for just the fourth time in their last 20 games.

Blue Jays 8, Yankees 5

At New York, Yunel Escobar hit a two-run homer, three doubles and drove in five runs as Toronto beat the New York Yankees, ending CC Sabathia's five years of dominance over the Blue Jays.

Escobar had a go-ahead RBI double in the third. His homer against Sabathia in the sixth gave the Blue Jays the lead again and his two-run double off Joba Chamberlain in the ninth helped secure Toronto's first series win since July 27-29.

White Sox 8, Orioles 1

At Baltimore, White Sox rookie Dylan Axelrod took a three-hitter into the eighth inning and Chicago spoiled the Baltimore debut of Joe Saunders, scoring seven runs off the left-hander.

Rays 8, Rangers 4

At Arlington, Texas, Evan Longoria homered twice, Tampa Bay roughed up Matt Harrison and the Rays beat the Rangers to snap a four-game losing streak.

Harrison (15-8) allowed seven runs and 12 hits in 51/3 innings. He took a no-hitter into the seventh and permitted two hits in eight shutout innings in his last outing Friday night against Minnesota.

Royals 1, Tigers 0

At Kansas City, Mo., Bruce Chen allowed four hits over a season-high eight innings, and Eric Hosmer's infield single in the fourth drove in the only run in the Royals' victory over the Tigers.

Angels 10, Red Sox 3

At Anaheim, Calif., Kendrys Morales and Chris Iannetta hit early two-run homers, C.J. Wilson snapped his 11-start winless skid and the Angels jumped all over new Boston starter Zach Stewart.

Torii Hunter, Alberto Callaspo and Erick Aybar all contributed run-scoring doubles during the three innings pitched by Stewart (0-1), who yielded 10 hits and fell behind 9-1 in a horrific Red Sox debut. Five Angels had multihit games, led by Hunter's 3-for-4 effort with two RBIs. Wilson (10-9) got plenty of help in his first victory since June 26, ending a dismaying two-month stretch of futility by the Angels' $77.5-million left-hander.

Giants 6, Astros 4

At Houston, Hunter Pence hit a three-run homer and Joaquin Arias drove in two with a triple to help San Francisco beat Houston.

Pence has been an Astros nemesis since they traded him in July 2011, hitting four homers in seven games against his former team with the Phillies and Giants.

The crowd of 13,207 was the smallest in the history of Houston's 12-year-old ballpark. The previous low came a night before.

George Kontos (1-0) struck out four in 22/3 scoreless innings for the win after Barry Zito yielded seven hits and three runs in a season-low 21/3 innings. Javier Lopez got two outs for his fifth save. Dallas Keuchel (1-7) retired 14 in a row after Pence's homer.

Reds 6, Diamondbacks 2

At Phoenix, Chris Heisey hit two of Cincinnati's four late homers, including a tying shot in the seventh inning, to rally the Reds to a win.

Dioner Navarro's solo shot two batters after Heisey's two-run drive put Cincinnati ahead. Brandon Phillips added a two-run homer in the eighth and Heisey capped the scoring with a solo homer two outs later.

Dodgers 10, Rockies 8

At Denver, Joe Blanton pitched effectively into the eighth inning for his first win with Los Angeles and A.J. Ellis hit his first career grand slam in a victory over Colorado.

Hanley Ramirez, another midseason acquisition by the Dodgers, homered in his second straight game to help Los Angeles overcome Matt Kemp's absence and withstand Colorado's seven-run eighth.

Pirates 5, Cardinals 0

At Pittsburgh, Pedro Alvarez kept up his recent tear, hitting his 26th homer and driving in three runs as Pittsburgh rolled to a victory over St. Louis.

Alvarez's three-run shot in the third gave him seven home runs and 23 RBIs in 15 games against St. Louis this year.

Nationals 8, Marlins 4

At Miami, Bryce Harper homered twice for the first time in his career and first-place Washington snapped a five-game losing streak by beating Miami.

Harper hit a two-run homer in the fourth inning and a solo shot in the fifth, giving the rookie 14 this season. He had a chance for a three-homer night but grounded into a double play in the ninth, spiked his helmet in frustration after crossing the bag and was ejected by umpire C.B. Bucknor.

Padres 8, Braves 2

At San Diego, Chase Headley and the Padres beat Atlanta for their ninth win in 10 games.

Headley hit a two-run single and left-hander Eric Stults (4-2) won his fourth straight decision as the Padres took two of three from the Braves, who lead the NL wild-card race.

Mets 3, Phillies 2

At Philadelphia, Lucas Duda hit a two-run homer, Matt Harvey had another sharp outing and New York beat the Phillies for its fourth straight win.

The Mets have won five straight in Philadelphia and seven of eight overall this season.

Brewers 3, Cubs 1

At Chicago, Mike Fiers tossed 71/3 solid innings to lead Milwaukee to its eighth straight victory over Chicago.

Fiers (8-6) held the Cubs to four hits and struck out six, helping Milwaukee beat its division rival for the 13th time in 16 meetings this season. The Brewers have won eight of nine overall and moved within five games of .500 for the first time since July 21.