TUCSON, Ariz. — Marcus Mariota came into Saturday's game with one of the most impressive streaks in college football, not having thrown an interception in 363 straight passing attempts.

TUCSON, Ariz. — Marcus Mariota came into Saturday's game with one of the most impressive streaks in college football, not having thrown an interception in 363 straight passing attempts.

It ended abruptly in the Ducks 42-16 loss to Arizona.

Mariota's first pass of the game was intercepted by Wildcats freshman linebacker Scooby Wright and returned 13 yards. Mariota's pass, intended for Bralon Addison, was tipped by Arizona cornerback Shaquille Richardson as he was falling out of bounds. Richardson batted the ball directly to Wright, who secured the pick.

"It is what it is; the guy made a great play," Mariota said of the first play. "I didn't really see the whole thing, I just saw the guy intercept it."

It was the start of a rough day Mariota.

He finished 27 for 41 for 308 yards, two touchdowns and two interceptions. He was also picked in the fourth quarter by Richardson on a second-and-1 from the Arizona 13-yard line.

Mariota, who had 25 touchdowns to no picks entering the game, now stands at 27 and two.

"I've never been blown out like this before in my life," Mariota said. "We are just going to have to come back and bounce back. We have to come back and just fight and control what we can control."

Mariota looked healthier than he had in recent weeks, but still sported a brace on his left knee. He finished with 52 yards on eight carries, including a long of 15.

Arizona didn't register a sack of Mariota in the win, but the Wildcats were able to get constant pressure on him, forcing him to throw before he was ready and scamper out of the pocket more than he'd like.

"We just didn't make the most of our opportunities," Mariota said. "We were missing reads and I have to get the ball to those guys. Sometimes when you miss those opportunities you don't get in a rhythm because our offense is very rhythm-based and when you can't push the ball down the field, you put a lot of strain on your defense."

Mariota's biggest misstep may have come right before halftime when on a fourth-and-2 from Arizona's 41-yard line, Mariota fumbled after a one-yard gain. De'Anthony Thomas recovered the ball and fell forward, but since a player can't advance a fumble, the ball was ruled down at the 40 and was handed back to Arizona, which went down and scored a touchdown to make it 28-9.

"That was huge," Oregon coach Mark Helfrich said. "We had a couple plays before that where we thought we had chances to make plays and then we couldn't quite make them. It gave the ball back to their offense to score."

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CAREY RUNS WILD: Arizona's Ka'Deem Carey, who led the nation in rushing last season, gashed Oregon for 206 yards on a career-high 48 carries.

It's the first time since Stanford's Toby Gehart ran for 223 yards in 2009 that the Ducks have given up 200 yards to an opposing rusher.

"Ka'Deem Carey was certainly as advertised as a ball carrier and we knew that coming in," Helfrich said.

Carey scored four touchdowns in Arizona's win.

"I knew we needed energy when you play a great team like them," Carey said. "I ran hard and with a passion today to help get the crowd in the game."

As a team, Arizona rushed for 304 yards. Quarterback B.J. Denker rushed for 102 yards on 14 carries.

The 304 yards were the most allowed by Oregon this season.

"We have to give Arizona a ton of credit," Helfrich said. "They were playing really hot today and their system worked really well."

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MARSHALL INJURED: Ducks starting running back Byron Marshall left the game early with an apparent right ankle injury.

Marshall had just three carries for four yards before exiting.

Marshall remained shy of 1,000 yards on the season and now has 995 through 11 games.

There wasn't an update on his status postgame.

In his absence, De'Anthony Thomas rushed for 83 yards, which were his most since he ran for 86 against Tennessee in Septemeber.

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QUICK HITS: The Ducks have now lost consecutive road games for the first time since 2007 when they lost to Arizona on Nov. 15 and UCLA on Nov. 24 ... Oregon's 19-point halftime deficit was its largest since trailing Indiana 23-0 in 2004 at Autzen Stadium ... Senior Josh Huff had three catches for 48 yards and is now ninth on Oregon's career receiving yards list with 2,076. He passed Lew Barnes, who had 2,048.