Two more Jackson County residents have died from COVID-19, and 108 new cases of the illness were reported Wednesday, according to Jackson County Public Health.

The deaths include an 84-year-old woman and a 48-year-old man who both had underlying medical conditions, public health officials reported. The woman tested positive Oct. 30 and died Nov. 12 at her home. The man tested positive Nov. 9 and died Nov. 15 at Providence Medford Medical Center. The deaths raise Jackson County’s COVID-19 death toll to 12.

The 108 new cases pushed Jackson County’s total number of cases past the 3,000-mark to 3,068. Of that number, 216 cases have required hospitalization.

Josephine County public health officials reported 17 new cases of the disease Wednesday. That raises the county’s running total to 377 cases.

On Wednesday, 53 COVID-19 patients in Jackson and Josephine counties were hospitalized for the illness, according to Oregon Health Authority data. One week ago, there were 32 hospitalized patients for the two-county region, referred to as Region 5 by OHA. Region 5, Region 1, which includes the Portland metropolitan area, and Region 2, which encompasses the Willamette Valley, were the areas in the state with the largest hospitalization increases due to the disease. The number of statewide hospitalizations because of the disease rose Wednesday to 406, a new record.

Of the 57 available intensive care unit beds in Jackson and Josephine county hospitals, 46 were occupied Wednesday, according to OHA data. Of the two-county region’s 447 available non-ICU beds, 390 were in use.

OHA officials reported 10 new deaths across the state from the illness Wednesday, with 1,099 new cases. The new deaths raised Oregon’s death toll to 788, and the case total rose to 59,669, OHA officials said.